Gynostemma Pentaphyllum (Thunb.) Makino (GpM) (Jiaogulan) has been widely used in Chinese medicine for the treatment of several diseases, including hepatitis, diabetes, and cardiovascular disease. Furthermore, GpM has recently been shown to exhibit potent anti-cancer activities. The general consensus from the literature is that GpM exerts its anti-cancer activities through multiple mechanisms, including cell cycle arrest, the induction of apoptosis, inhibition of invasion and metastasis, glycolysis inhibition, and immunomodulation. Gynostemma Pentaphyllum is a plant distantly related to the cucumber. In traditional Asian medicine, it’s used to promote longevity. Today’s scientists have discovered why Asian doctors prescribed G. Pentaphyllum to address age-related health issues: It promotes AMPK activation. G. Pentaphyllum not only activates AMPK, but it also shuttles excess fats into the mitochondria to be utilized for energy and safe disposal. The result is efficient energy production and a sharp reduction in unnecessary fat storage. Results of G. Pentaphyllum-induced AMPK activation include increased fat burning, as well as an increase in cellular glucose uptake. Extracts of G. Pentaphyllum have other beneficial properties as well, including the ability to prolong cellular life in the face of stresses induced by oxidation, fat accumulation, and diabetes. When scientists began exploring the benefits of G. Pentaphyllum for AMPK activation, they turned to animal studies. What they found was that leaf extracts of G. Pentaphyllum activate AMPK, resulting in reduced body weight gain and fat accumulation.78 In a preclinical study, obese mice supplemented with G. Pentaphyllum showed impressive declines in markers associated with obesity and its related diseases. In another study, this time using diabetic rats, three weeks of G. pentaphyllum supplementation resulted in improved glucose tolerance by 35% and reduced new glucose production in the liver by 29%, with a reduction in liver glycogen, the storage form of sugar. These results show the enormous beneficial impact of reducing circulating sugar and fats in response to AMPK activation by G. pentaphyllum. Human studies have confirmed what many of the researchers had found in the lab: G. pentaphyllum boosts AMPK activity and provides important longevity benefits. In a compelling human study, type II diabetics who were not using diabetic medications drank a tea made with G.pentaphyllum. Gynostemma Pentaphyllum (Jiaogulan), a Chinese Herb of immortality. Is a slightly bitter herb, popular in Kombucha Tea as a natural energizer. Used a the Secret Russian Olympian Extract. Releases AMP-activated protein kinase (AMPk). AMPk "master metabolic regulator" turns on fat-burning and energy-releasing metabolic processes.